Endothelial Cell Aging: How miRNAs Contribute?

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

miRNAs in endothelial cell signaling: the endomiRNAs.

microRNAs (miRNAs) have a pivotal role during the formation and function of the cardiovascular system. More than 300 miRNAs have been currently found within the mammalian genome, however only few specific miRNAs, named endomiRNAs, showed conseved endothelial cell expression and function. In this review we present an overview of the currently known endomiRNAs, focusing on their genome localizati...

متن کامل

KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.

Kaposi sarcoma herpesvirus (KSHV) induces transcriptional reprogramming of endothelial cells. In particular, KSHV-infected lymphatic endothelial cells (LECs) show an up-regulation of genes associated with blood vessel endothelial cells (BECs). Consequently, KSHV-infected tumor cells in Kaposi sarcoma are poorly differentiated endothelial cells, expressing markers of both LECs and BECs. MicroRNA...

متن کامل

Impact of miRNAs on cardiovascular aging

Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs (miRNAs) have been shown to regulate gene expression, which contributes to many physiological and pathophysiological processes in humans. Increasing evidence suggest...

متن کامل

How Cell Biologists Can Contribute to Improving Cancer Outcomes

It is now clear that there are hundreds of different types of cancer. This is a dramatic departure from the prevailing view in 1971 when the U.S. “war on cancer” was first launched and it was widely believed that cancers had a common cause and would likewise have a common cure. Knowledge of tumor complexity has fueled optimism for the development of targeted and personalized treatments based on...

متن کامل

miRNAs halt cell cycle

608 Cells lacking miRNAs (bottom) do not differentiate into muscle (right). miRNAs halt cell cycle M uscle-specifi c miRNAs can induce differentiation at least in part by depleting DNA polymerase α mRNA, according to Kim et al. (page 677). Although other factors are also involved in the differentiation process, obliterating the DNA replication machinery is a novel means to bring the cell cycle ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Clinical Medicine

سال: 2018

ISSN: 2077-0383

DOI: 10.3390/jcm7070170